2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2799A
    Creatine Kinase (CPK/CK), Bovine Heart 9001-15-4
    Creatine Kinase (CPK/CK), Bovine Heart (CK) is a creatine kinase derived from bovine heart. Creatine Kinase (CPK/CK), Bovine Heart catalyzes the reversible phosphate transfer reaction between phosphocreatine and ADP, and is widely used in myocardial energy metabolism research and quality control of clinical biochemical tests.
    Creatine Kinase (CPK/CK), Bovine Heart
  • HY-123669A
    trans-R-138727 239466-74-1 98.98%
    Trans-R-138727 is the trans isomer of R-138727 (HY-123669). R-138727 is the active metabolite of the antiplatelet agent Prasugrel (HY-15284). R-138727 is an irreversible inhibitor for the platelet receptor P2Y12, and inhibits ADP-induced platelet activation and aggregation.
    trans-R-138727
  • HY-132587A
    Fitusiran sodium
    Fitusiran (ALN-AT3SC) sodium is a siRNA strategy. Fitusiran delivers siRNA targeting the SERPINC1 gene in hepatocytes to inhibit antithrombin synthesis. Fitusiran sodium enhances thrombin activity and increases Thrombin generation, thereby restoring hemostatic function. Fitusiran sodium can be used in hemophilia-related research.
    Fitusiran sodium
  • HY-N0830S4
    Palmitic acid-d2 62689-96-7 99.8%
    Palmitic acid-d2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d2
  • HY-P990294
    Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)
    Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis.
    Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)
  • HY-W018723
    4-Aminobenzamidine dihydrochloride 2498-50-2 ≥98.0%
    4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor. 4-Aminobenzamidine dihydrochloride acts as an orally active urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM). 4-Aminobenzamidine dihydrochloride can be used for cardiovascular diseases and anti-tumor study.
    4-Aminobenzamidine dihydrochloride
  • HY-W024271
    8-Hydroxyjulolidine-9-carboxaldehyde 63149-33-7 99.93%
    8-Hydroxyjulolidine-9-carboxaldehyde (9-Formyl-8-hydroxyjulolidine) is a highly selective fluorescent probe for hydrogen sulfide (S2−) and silicate (SiO32−). 8-Hydroxyjulolidine-9-carboxaldehyde operates via a mechanism of blocking intramolecular charge transfer (ICT), exhibiting significant fluorescence enhancement in the presence of weak acid ions. 8-Hydroxyjulolidine-9-carboxaldehyde is promising for research of fluorescence imaging of hydrogen sulfide within living cells.
    8-Hydroxyjulolidine-9-carboxaldehyde
  • HY-W004284S1
    Heptadecanoic acid-d33 352431-41-5 99.88%
    Heptadecanoic acid-d33 is the deuterium labeled Heptadecanoic acid. Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis.
    Heptadecanoic acid-d33
  • HY-66010
    Cinepazide Maleate 26328-04-1 99.74%
    Cinepazide Maleate (MD-67350) is a piperazine derivative and acts as a weak calcium channel blocker. Cinepazide Maleate is a potent vasodilator and can be used for the research of cerebrovascular diseases, including ischemic stroke, brain?infarct et. al.
    Cinepazide Maleate
  • HY-B0908
    Meticrane 1084-65-7 98.93%
    Meticrane is a diuretic. Meticrane inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.
    Meticrane
  • HY-B1116
    Metaraminol tartrate 33402-03-8 ≥98.0%
    Metaraminol tartrate?(Metaradrine tartrate) is an α-adrenergic agonist. Metaraminol tartrate is a sympathomimetic amine that directly and indirectly affects adrenergic receptors, with alpha effects being predominant.Metaraminol tartrate acts as a vasopressor agent.
    Metaraminol tartrate
  • HY-B1170
    Cyclandelate 456-59-7 98.66%
    Cyclandelate is a vasodilator that can be used in the study of claudication, arteriosclerosis, Raynaud's disease, nocturnal leg cramps, and migraines.
    Cyclandelate
  • HY-N0204
    Pulchinenoside A 129724-84-1 98.81%
    Pulchinenoside A (Anemoside A3) is an orally active triterpenoid glycoside found in the root of Pulsatilla chinensis. Pulchinenoside A has amti-inflammation, antitumor, antidepressant, immunoregulatory and neuroprotective efrects. Pulchinenoside A activates NF-κB/MAPK signaling pathway. Pulchinenoside A can induce relaxing effect in rat renal arteries. Pulchinenoside A can be used for the researches of experimental autoimmune encephalomyelitis, breast cancer, depression and renovascular hypertension.
    Pulchinenoside A
  • HY-100613
    MONNA 1572936-83-4 99.87%
    MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC50 of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
    MONNA
  • HY-126356
    1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine 35418-59-8 99.9%
    1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is a major phospholipid in low-density lipoprotein and belongs to the group of 1-acyl phosphatidylcholines. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine does not induce morphological changes in washed human platelets. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine can be used for the research of atherosclerosis and thrombotic diseases.
    1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
  • HY-Y0271R
    Urea (Standard) 57-13-6 99.87%
    Urea (Standard) is the analytical standard of Urea. This product is intended for research and analytical applications. Urea is a powerful protein denaturant via both direct and indirect mechanisms. A potent emollient and keratolytic agent. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
    Urea (Standard)
  • HY-W004580
    5,5'-Dicarboxy-2,2'-bipyridine 1802-30-8 ≥98.0%
    5,5'-Dicarboxy-2,2'-bipyridine is a niacin derivative, which is promising for research of hypercholesterolemia, hyperlipidemia, and cardiovascular disease.
    5,5'-Dicarboxy-2,2'-bipyridine
  • HY-W010347R
    L-Homocysteine (Standard) 6027-13-0 98.83%
    L-Homocysteine (Standard) is the analytical standard of L-Homocysteine. This product is intended for research and analytical applications. L-Homocysteine, an amino acid, is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia[1][2].
    L-Homocysteine (Standard)
  • HY-107414
    SKA-121 1820708-73-3 99.69%
    SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.
    SKA-121
  • HY-112885A
    nor-NOHA acetate 1140844-63-8 ≥99.0%
    nor-NOHA acetate is a selective and reversible Arginase inhibitor. nor-NOHA acetate induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA acetate has anti-leukemic activity. nor-NOHA acetate improves liver ischemia-reperfusion injury. nor-NOHA acetate can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism.
    nor-NOHA acetate
Cat. No. Product Name / Synonyms Application Reactivity